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Influenza A virus infection modulates membrane regulations of complement activation
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"The complement system is a key component of the
immune response as it bridges innate and adaptive immunity.
Moreover, it also plays a crucial role in modulating the intensity of
immunological and inflammatory processes by communicating
with immune cells. These interactions are beginning to be fully
appreciated, and their identification is crucial, as excess
complement activation is associated with severe outcomes in
many infections. In order to avoid immune-mediated damage to
the host, the complement cascade must be tightly regulated. The
self-targeting deleterious effects of complement are avoided via a
series of complement regulators (C-regs). Amongst the C-regs
complement decay-accelerating factor (DAF/CD55) and CD59
block the complement cascade at the central and terminal points,
respectively, and localise ubiquitously at the apical surface of
polarised cells. The lack of DAF and CD59 is associated with
over-stimulation of complement resulting in increased
inflammatory responses and worse outcome in several models of
infection and autoimmunity. In this work we have focused on the
role of DAF and CD59 in the context of IAV infection(...)"
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Palavras-chave
IAV infection Infections