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Stem cell bioprocessing strategies for cardiac regeneration
| Nome: | Descrição: | Tamanho: | Formato: | |
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| 6.29 MB | Adobe PDF |
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Resumo(s)
"Cardiovascular diseases (CVD) are the leading cause of morbidity and
mortality worldwide. Within CVD, myocardial infarction (MI) is associated with a
massive and permanent loss of cardiomyocytes (CM). Advanced therapies based
(...)
numerous preclinical studies. Nonetheless, their clinical efficacy to improve the
heart function remains elusive and controversial. The lack of validated and
standardized cell culture protocols and characterization tools are among the
contributing factors for this translational failure. Moreover, understanding the key
cellular mechanisms underlying cardiac regeneration may also expose a
multiplicity of therapeutic targets, paving the way for improved therapies by
controlling cardiac tissue remodeling and/or to impose a pro-regenerative state.
This thesis aimed at the implementation of novel strategies that could
contribute for improved cardiac regenerative therapies. This work was divided
into two main sections covering (A) the implementation of robust and scalable
protocols for the expansion of human stem cells and (B) the interrogation of the
functional role of a putative therapeutic molecule, CCBE1 (collagen and calcium-
EGF binding domain 1), on cardiac commitment.(...)"
Descrição
Palavras-chave
regenerative therapies cardiac regeneration