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Determination of cell shape in Staphylococcus aureus
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Resumo(s)
"Cell size and morphology are two extremely important
characteristics in the adaptation of bacteria to the external environment
and are often associated to bacterial survival and growth. In
Staphylococcus aureus, a common colonizer of human skin and mucus
membranes, the small spherical shape of cells may be an advantage
during colonization, helping this pathogen to evade host immune
system. The fact that cell shape is maintained over consecutive
generations evidences the existence of tightly regulated underlying
mechanisms. Bacterial shape is maintained by the existence of an
external cell wall mainly composed of peptidoglycan (PGN), a mesh-like
molecule made by glycan chains cross-linked by short peptide bridges.
Localization of PGN synthesis is dependent on the action of cytoskeletal
proteins, which direct the activity of proteins involved in this synthesis,
including Penicillin-Binding Proteins (PBPs) and proteins from the
shape, elongation, division and sporulation (SEDS) family, to specific
regions of the cells. T(...)"
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Staphylococcus aureus Cell shape