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Insights into the biological significance of alternative splicing in Arabidopsis: functional characterization of a dual-targeted E3 ligase and the SCL30a SR protein
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Resumo(s)
RNA splicing is an essential step in eukaryotic gene
expression during which introns are precisely removed from the
precursor-mRNA (pre-mRNA) and exons joined together to form
the mature mRNA molecule. The presence of numerous exons per
gene enables the splicing machinery to process the same premRNA
differently by selectively removing different intronic
sequences, thus generating multiple transcripts, and eventually
more than one protein, from a single gene. Such alternative
splicing pathways have emerged as a key mechanism for
generating proteome diversity and functional complexity. The
prevalence of alternative splicing in many genomes, including
those of higher plants, suggests that this mechanism plays crucial
roles in biological processes.
To adapt to an environment in constant change, plants, as
sessile organisms, have evolved high degrees of both
developmental plasticity and stress tolerance, which are ultimately
regulated at the genome level. The exceptional versatility
associated with gene regulation by alternative splicing is likely to
play a prominent role in plant responses to environmental cues, but
the biological significance of this posttranscriptional regulatory
mechanism in plants remains poorly understood.(...)
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Dissertation presented to obtain the Ph.D degree in Molecular Biology
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica