ITQB: Bio C - PhD Theses
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- Metal Complexes Stabilized by Nucleobases and Their Analogues: Synthesis and ApplicationsPublication . Francescato, Giulia; Petronilho, Ana"This thesis work is structured into four main sections. The first chapter is a general introduction, initiated with a discussion of the structure and the electronic properties of N-heterocyclic carbenes (NHCs). Furthermore, it focuses on the importance of NHCs in organometallic chemistry and the use of NHCs as ligands for metal complexes with potential biological applications. The introductory chapter also contains a review of key examples of metal complexes containing nucleobases and their analogues. This synopsis explores both the synthesis and the biological application of these complexes. Finally, the aim of this thesis work is outlined: synthesize new metal complexes containing nucleobases or analogues as NHCs and study their biological applications.(...)"
- Organometallic Nucleosides: Synthesis of Platinum and Palladium complexes bearing N- Heterocyclic carbenes based on nucleosides and their anticancer activityPublication . Leitão, Maria Inês P. S.; Orientadora: Petronilho, Ana" Alkylation of DNA nucleobases is a common modification of the genome that results in formation of the so-called DNA adducts. Structurally, some of these adducts are N-heterocyclic carbene precursors, whose reactivity is scarcely studied. The work reported in this thesis is devoted to the synthesis of nucleoside-based NHC complexes based on palladium and platinum and to the study of their activity as anticancer agents. "
- Synthesis of new bioactive autoinducer-2 analoguesPublication . Miranda, Vanessa" Bacteria behaviours are regulated on a communitywide scale by producing, secreting, detecting and responding to extracellular small signaling molecules (autoinducers) that accumulate in the environment in proportion to cell density. This process is called quorum sensing (QS). (...)"