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Time in the basal ganglia
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Resumo(s)
"To behave adaptively, animals must learn the temporal structure of events in their
environment, and they must also predict the sometimes delayed consequences of their
own actions. Therefore, to produce adaptive behavior, it is essential that the brain
maintains a representation of time. How does the brain represent elapsed time in a
manner that supports adaptive behavior, and what are the mechanisms that contribute
to variability in subjective time estimates? In this monograph I address the roles of
striatal and midbrain dopamine (DA) neurons in timing behavior. First, we recorded
the activity of striatal neurons in rats performing an interval production task. We found
that these neurons responded at different delays spanning the interval being timed. In
addition, individual neurons rescaled their responses in time when intervals changed,
indicating that relative time can be decoded from striatal populations. Next, we both
measured and manipulated the activity of DA neurons in the substantia nigra pars
compacta (SNc) while mice performed a temporal categorization task.(...)"
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Palavras-chave
Neurons Midbrain