The mercapturomic profile of health and non-communicable diseases

The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.

Descrição

iNOVA4Health–UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is acknowledged (Ref: 201601-02-021). Authors supported by Fundação para a Ciência e a Tecnologia (FCT–Portugal): for V.S.; PD/BD/105892/2014 for C.G.-D.;RNEM-LISBOA-01-0145-FEDER-022125022125 for J.M.; SFRH/BD/130911/2017 for M.J.C.; D/BD/114257/2016 for N.R.C.; Programa Operacional Potencial Humano and the European Social Fund (IF/01091/2013) for A.M.M.A.

Palavras-chave

Biomarkers Chronic inflammation Cysteine-S-conjugates Cysteinyl-leukotrienes Disulfides Dopamine Estrogen Mercapturate pathway Metabolomics N-acetyl-transferase 8 Biotechnology Bioengineering Biochemistry Biomedical Engineering SDG 3 - Good Health and Well-being