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Functional studies on BolA and related genes: increasing the understanding of a protein with pleiotropic effects
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BolA is a protein that is able to change bacterial shape, confer resistance against large antibiotic molecules and detergents, reduce permeability, change the equilibrium of the outer membrane porins, and it is even involved in biofilm formation. This protein has such pleiotropic effects, that its function has been very difficult to unravel. This was the starting point for the work of this dissertation. If bolA is responsible for global cellular changes that confer resistance to a multitude of stresses, it is imperative to obtain more molecular insights to increase the understanding of the role of BolA in cell physiology and survival.(...)
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Dissertation presented to obtain a Doctoral degree in Biology by Instituto de Tecnologia Química e Biológica
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica