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Immune response and tissue cytoprotection: two sides of the same coin in immunopathology
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Resumo(s)
The immune system is fundamental to maintaining the
host’s viability upon infection. Nonetheless, the mechanisms
used to control pathogens may also cause tissue damage,
leading to the development of immunopathology. The host’s
capacity to survive infections depends on its ability to control the
pathogen burden, while avoiding the deleterious effect of immune
responses on its own tissues. To achieve this goal, the host may
apply the following strategies: increasing tissue resilience to
immune-mediated insult and/or controlling exacerbated immune
activation. This Thesis sought insight into the mechanisms used
by the host to successfully employ both strategies(...)
Descrição
Dissertation presented to obtain the Ph.D degree in Biochemistry
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica