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Title: Crystallographic studies on two hyperthermophilic enzymes
Author: Brito, José A.
Advisor: Archer, Margarida
Defense Date: Sep-2011
Publisher: Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica
Abstract: While Aristotle cautioned “everything in moderation”, the Romans, known for their eccentricities, coined the word “extremus”, the superlative of exter, “being on the outside”. By the fifteenth century “extreme” had arrived to English, via Middle French. At the beginning of the 21st century, we know that Earth contains environmental extremes unimaginable to our ancestors of the 19th century. Even more unimaginable to them would be the fact that there are organisms that live, and grow, in these environmental extremes. R. D. MacElroy named these organisms lovers (from the Greek “philos”), “extremophiles” as in “lovers of extreme environments”. The discovery of extremophiles has put vitality in the biotechnology industry as this discipline has exploded in the past 20 years. Several reviews have been published on extremophiles and an increasing number of meetings and conferences are organised around the theme. Genomes of extremophiles have been sequenced, patents have been filed and several funding programmes have been launched namely the US National Science Foundation and NASA’s programmes in “Life in Extreme Environments, Exobiology and Astrobiology”, and the European Union’s “Biotechnology of Extremophiles” and “Extremophiles as Cell Factories”(...)
Description: Dissertation presented to obtain the Ph.D degree in Biochemistry
Appears in Collections:ITQB: MPC - PhD Theses

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