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Chromatin dynamics in Arbidopsis development: a live cell imaging approach
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Resumo(s)
The proper development of multicellular organisms demands the distinct specification
of a variety of specialized cell types. While this is one of the oldest statements of
developmental genetics, how different patterns of gene expression are established in
genetically identical cells and maintained during somatic cell divisions is still an active topic
of research.
Chromatin structure is now recognized to regulate gene activity playing a crucial role
in cell differentiation and development. Chromatin is not simply a packaging tool but a
dynamic entity that reflects the regulatory cues necessary to program appropriate cellular
pathways. There are several ways by which chromatin structure can be remodelled. These
mechanisms include DNA-methylation, post-translational modifications of histone proteins,
histone variants and, nuclear localization. While the dynamic nature of chromatin structure
has been previously described its biological function and repercussions on development are
only now beginning to be revealed. In this work we used in vivo microscopy techniques to
assess how different aspects of chromatin organization play a role on various aspects of development.(...)
Descrição
Dissertation presented to obtain the Ph.D degree in Biology
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica