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Metabolism of primary astrocytes studied by NMR: metabolic trafficking and neuroprotection
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The human brain is the product of 600 million years of evolution and it is by far the
most complex structure in the known universe. The vertebrates’ brain is composed of
several different cell types, which perform the different functions required. The two
most abundant cell types are neurons, which are the brain function unit, and glial
cells, which are responsible for a myriad of housekeeping, homeostatic and
structural functions. Glial metabolism is so far interconnected with the neuronal
metabolism, that it is difficult to state where one finishes and the other starts.
Trafficking between the two compartments include metabolites of almost all
metabolic pathways (glycolysis, TCA, amino acids, ketone bodies, etc) and also
ions.(...)
Descrição
Dissertation presented to obtain a Ph. D. degree in Biochemistry by Universidade
Nova de Lisboa, Instituto de Tecnologia Química e Biológica.
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica