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THE ROLE OF THE FLAVODIIRON PROTEINS IN NITRIC OXIDE DETOXIFICATION
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| 10.44 MB | Adobe PDF |
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Resumo(s)
"This dissertation portrays recent developments on the knowledge of a protein
family whose once elusive role is presently clearer, although still prone to
discussion. The family of Flavodiiron Proteins (FDPs), initially thought to protect
anaerobes from oxygen exposure, have been proposed to have a role in nitric
oxide detoxification. The main object of study of this dissertation, Escherichia coli
Flavorubredoxin (FlRd) made a large contribution to establish this role. FlRd was
the first member of the FDP family to be assigned as an NO reductase, followed
by the demonstration of the same activity in other FDPs, although a role in
oxygen scavenging by other FDP family members has to be considered.(...)"
Descrição
Palavras-chave
Proteins Nitric Oxide