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Functional and structural characterization of the RNase II-family of enzymes
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Ribonucleases (RNases) are ubiquitous and have a central role in the
control of gene expression. They are involved in the maturation of
functional RNAs as well as their degradation. RNases are also involved in
quality control mechanisms and are crucial to the recycling of
ribonucleotides, key cellular metabolites. Ribonucleases can be broadly
classified as endoribonucleases, which cleave at sites internal to the RNA,
or exoribonucleases, which remove nucleotides from either the 5' end or 3'
end of the RNA molecule. Enzymes from the RNase II-family of
exoribonucleases are present in all domains of life, and processively
degrade RNA in the 3’ to 5’ direction with a hydrolytic activity that releases
5’-nucleotide monophosphates. They play a crucial role in RNA metabolism
and have been shown to be required for normal growth and viability,
virulence, mitotic control and chloroplast biogenesis.(...)
Descrição
Dissertation presented to obtain a Doctoral Degree in Biology by Instituto
de Tecnologia Química e Biológica, Universidade Nova de Lisboa
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica