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Title: Functional and structural characterization of the RNase II-family of enzymes
Author: Matos, Rute Gonçalves
Advisor: Arraiano, Cecília M.
Barbas, Ana
Defense Date: Sep-2011
Publisher: Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica
Abstract: Ribonucleases (RNases) are ubiquitous and have a central role in the control of gene expression. They are involved in the maturation of functional RNAs as well as their degradation. RNases are also involved in quality control mechanisms and are crucial to the recycling of ribonucleotides, key cellular metabolites. Ribonucleases can be broadly classified as endoribonucleases, which cleave at sites internal to the RNA, or exoribonucleases, which remove nucleotides from either the 5' end or 3' end of the RNA molecule. Enzymes from the RNase II-family of exoribonucleases are present in all domains of life, and processively degrade RNA in the 3’ to 5’ direction with a hydrolytic activity that releases 5’-nucleotide monophosphates. They play a crucial role in RNA metabolism and have been shown to be required for normal growth and viability, virulence, mitotic control and chloroplast biogenesis.(...)
Description: Dissertation presented to obtain a Doctoral Degree in Biology by Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa
Appears in Collections:ITQB: CGE - PhD Theses

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