Protein- and Peptide-Based Biosensors in Artificial Olfaction

Barbosa, Arménio J. M.; Oliveira, Ana Rita; Roque, Ana C. A.

doi:https://doi.org/10.1016/j.tibtech.2018.07.004

Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/58659

Título:	Protein- and Peptide-Based Biosensors in Artificial Olfaction
Autor:	Barbosa, Arménio J. M. Oliveira, Ana Rita Roque, Ana C. A.
Palavras-chave:	artificial olfaction biosensor odorant-binding protein olfactory receptor peptide Volatile organic compounds Biotechnology Bioengineering
Data:	1-Dez-2018
Citação:	Barbosa, A. J. M., Oliveira, A. R., & Roque, A. C. A. (2018). Protein- and Peptide-Based Biosensors in Artificial Olfaction. Trends In Biotechnology, 36(12), 1244-1258. https://doi.org/10.1016/j.tibtech.2018.07.004
Resumo:	Animals' olfactory systems rely on proteins, olfactory receptors (ORs) and odorant-binding proteins (OBPs), as their native sensing units to detect odours. Recent advances demonstrate that these proteins can also be employed as molecular recognition units in gas-phase biosensors. In addition, the interactions between odorant molecules and ORs or OBPs are a source of inspiration for designing peptides with tunable odorant selectivity. We review recent progress in gas biosensors employing biological units (ORs, OBPs, and peptides) in light of future developments in artificial olfaction, emphasizing examples where biological components have been employed to detect gas-phase analytes.
Descrição:	info:eu-repo/grantAgreement/FCT/5876/147258/PT This work was supported by the European Research Council through the grant reference SCENT-ERC-2014-STG-639123 (2015-2020), and by the Unidade de Ciências Biomoleculares Aplicadas-UCIBIO, which is financed by national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement ( POCI-01-0145-FEDER-007728 ). A.J.M. Barbosa and A.R. Oliveira thank fellowships SFRH/BPD/112543/2015 and SFRH/BD/128687/2017 from FCT/MCTES , Portugal.
Peer review:	yes
URI:	http://www.scopus.com/inward/record.url?scp=85056602481&partnerID=8YFLogxK
DOI:	https://doi.org/10.1016/j.tibtech.2018.07.004
ISSN:	0167-7799
Aparece nas colecções:	FCT: DQ - Artigos em revista internacional com arbitragem científica

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