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Protein- and Peptide-Based Biosensors in Artificial Olfaction
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Orientador(es)
Resumo(s)
Animals' olfactory systems rely on proteins, olfactory receptors (ORs) and odorant-binding proteins (OBPs), as their native sensing units to detect odours. Recent advances demonstrate that these proteins can also be employed as molecular recognition units in gas-phase biosensors. In addition, the interactions between odorant molecules and ORs or OBPs are a source of inspiration for designing peptides with tunable odorant selectivity. We review recent progress in gas biosensors employing biological units (ORs, OBPs, and peptides) in light of future developments in artificial olfaction, emphasizing examples where biological components have been employed to detect gas-phase analytes.
Descrição
info:eu-repo/grantAgreement/FCT/5876/147258/PT This work was supported by the European Research Council through the grant reference SCENT-ERC-2014-STG-639123 (2015-2020), and by the Unidade de Ciências Biomoleculares Aplicadas-UCIBIO, which is financed by national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement ( POCI-01-0145-FEDER-007728 ). A.J.M. Barbosa and A.R. Oliveira thank fellowships SFRH/BPD/112543/2015 and SFRH/BD/128687/2017 from FCT/MCTES , Portugal.
Palavras-chave
artificial olfaction biosensor odorant-binding protein olfactory receptor peptide Volatile organic compounds Biotechnology Bioengineering