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Development of CO-releasing molecular for the treatment of inflammatory diseases
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Carbon Monoxide, CO, has been recognized as an endogenously produced, potent
biological mediator involved in many defense mechanisms both in physiologic
and pathologic situations. As a result of these signaling processes, CO possesses a
strong therapeutic potential on a wide range of disease indications. However, the
hardly avoidable safety and practical problems associated with therapeutic
inhalation of toxic CO gas, led to the search for molecules capable of delivering
CO to tissues in a living organism in a controlled and therapeutically useful
manner. From all the areas of the chemical space where such CO-Releasing
Molecules (CO-RMs) can be found, Metal Carbonyls Complexes (MCCs) seems
to be the most versatile.
It is the purpose of this Thesis to provide an extensive characterization of the
behavior of MCCs in the presence of biological molecules and media, in order to
identify the chemical and structural parameters that are more relevant to define
the profile of a therapeutically effective metal-based CO-RM drug.(...)
Descrição
Dissertation presented to obtain a Ph.D. degree (Doutoramento) in Chemistry
at the Instituto de Tecnologia Quimica e Biol6gica da Universidade Nova de Lisboa
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica