A carregar...
Publicação
Massive shift in the pneumococcal nasopharyngeal flora after the 7-valent conjugate vaccine: epidemiological studies and testing pathogenic potential in animal models
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 4.12 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
Although it exists mostly as a commensal bacterium colonizing the human nasopharynx,
particularly in children, the Gram-positive bacterium Streptococcus pneumoniae, is also
a major human pathogen that can cause a wide range of diseases, which include otitis
media, sinusitis, pneumonia, and such life-threatening afflictions as bloodstream
infection and meningitis.
Created to protect children against pneumococcal disease, the 7-valent pneumococcal
conjugate vaccine (PCV7) showed high efficacy in preventing disease caused by the
serotypes included in the vaccine, the so-called vaccine types (VTs). Since colonization
is an essential first step to develop pneumococcal disease, it is of importance to
investigate the effect of this vaccine on the degree of colonization, on changes in the
composition of the nasopharyngeal flora and the virulence potential of the non vaccine
type (NVT) strains.(...)
Descrição
Dissertation presented to obtain the PhD degree in Biology/Molecular Biology by
Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica
Palavras-chave
Contexto Educativo
Citação
Editora
Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica