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Metabolic and morphogenetic engineering of Bacillus subtilis: biotechnology for industry
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| 3.09 MB | Adobe PDF |
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Resumo(s)
The bacterium Bacillus subtilis plays a major role as model
for Gram-positive research, and is widely used as industrial
workhorse for the production of high-value enzymes and
metabolites. Successful development of commercially-attractive
strains and of original products is the key of innovation in microbial
industry. Evolving a natural B. subtilis strain into an overproducer
involves genetic engineering. In spite of a wide range of genetic
tools and techniques available for B. subtilis, engineering of the
metabolic pathways, with the purpose to reach industrially
significant amount of products, requires a deep and specific
understanding of the metabolism.(...)
Descrição
Dissertation presented to obtain the Ph.D. degree in “Biology”
at the Institute of Chemical and Biological Technology
of the New University of Lisbon
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica