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Studies on resistance and response to vancomycin in Enterococcus faecalis: a last resort antibiotic
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| 11.45 MB | Adobe PDF |
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Resumo(s)
Enterococci are part of the normal human and animal gut microbiota and
hardly cause infections in healthy individuals. In the last 20 years enterococci
have emerged as common causes of hospital-acquired infections. One of the
major reasons why these microorganisms easily survive in the hospital
environment is their intrinsic resistance to several commonly used antibiotics, and
more importantly, their ability to acquire resistance to many currently used
antibiotics, including glycopeptides.
Development of resistance to the glycopeptide vancomycin in the
Enterococcus genus presents a worldwide major problem. Infections with
vancomycin resistant enterococci are not only difficult to treat but the organisms
show a strong propensity to disseminate and spread from patient to patient in the
hospital setting. Accurate knowledge of the real scenario of vancomycin
resistance is essential to design national and global strategies and prevent
community and nosocomial transmission of vancomycin resistant organisms.(...)
Descrição
Dissertation presented to obtain a Ph.D. degree in Biochemistry by
Instituto de Tecnologia Química e Biológica
Universidade Nova de Lisboa.
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica