Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/5156
Título: Unravelling novel modes of antimicrobial action
Autor: Nobre, Lígia S.
Orientador: Saraiva, Lígia M.
Data de Defesa: Nov-2010
Editora: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa
Resumo: The work presented in this thesis aimed at unravelling novel modes of antimicrobial action through: i) the study of Staphylococcus aureus defences against nitric oxide, an antimicrobial weapon of the innate immune system, namely by performing the biochemical characterisation of S. aureus NO-detoxifying flavohaemoglobin and analysing the conditions under which the enzyme is operative; ii) the identification of the mechanisms beyond the antibacterial activity of azole antibiotics towards S. aureus that were shown to include the increase of endogenous reactive oxygen species triggered by the binding of imidazoles to flavohaemoglobin; and iii) the discovery of a novel type of bactericides, the carbon monoxide-releasing molecules, and identification of its potential cellular targets via analysis of the transcriptional response of Escherichia coli to CORM-2, a carbon monoxide-releasing molecule known to mimic the physiological function of carbon monoxide.(...)
Descrição: Dissertation presented to obtain the Ph.D. degree in Biochemistry at the Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa
URI: http://hdl.handle.net/10362/5156
Aparece nas colecções:ITQB: MGMR - PhD Theses

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Nobre_2010.pdf4,21 MBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.