A carregar...
Publicação
Tracing protein evolutionary trajectory
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 3.79 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
Evolutionary processes can be considered at multiple levels of biological organization.
The work developed in this thesis focuses on protein molecular
evolution. Although proteins are linear polymers composed from a basic set of
20 amino acids, they generate an enormous variety of form and function. Proteins
that have arisen by a common descent are classified into families; they often
share common properties including similarities in sequence, structure, and function.
Multiple methods have been developed to infer evolutionary relationships
between proteins and classify them into families. Yet, those generic methods are
often inaccurate, especially when specific protein properties limit their applications.
In this thesis, we analyse two protein classes that are often difficult for the
evolutionary analysis: the coiled-coils – repetitive protein domains defined by a
simple widespread peptide motif (chapters 2 and 3) and Rab small GTPases –
a large family of closely related proteins (chapters 4 and 5). In both cases, we
analyse the specific properties that determine protein structure and function and
use them to improve their evolutionary inference.
Descrição
Palavras-chave
Biology Bioinformatics