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Unfolding the physiological roles of the binding of Atl to eDNA in Staphylococcus aureus
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Staphylococcus aureus is usually a commensal organism of the human’s
microbiota, although it can become invasive when the host’s defenses are
breached, becoming an important nosocomial opportunistic pathogen, with
high morbidity and mortality rates across the globe. It is responsible for a wide
array of infections that range from minor skin and soft tissue infections to
more severe ones, such as endocarditis, osteomyelitis and sepsis. This
microorganism harbors a plethora of virulence factors that alongside its
capacity to acquire resistance to virtually all antibiotics have enabled it to
become one of the most prominent pathogens of this era. In fact, S. aureus is
one of the major causes for infections associated with indwelling devices,
which are usually related with biofilm development. Biofilms are multicellular
sessile microbial communities in which cells are attached to a surface and/or
to other cells and encased within a self-produced protective extracellular
matrix. The biofilm forming capacity of S. aureus is part of the myriad of
virulence mechanisms that enables this bacterium to resist both antibiotic
treatment and the action of the host immune system.
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Biology