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The computational role of short-term plasticity and the balance of excitation and inhibition in neural microcircuits: experimental and theoretical analysis
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The computations performed by the brain ultimately rely on the
functional connectivity between neurons embedded in complex networks. It is
well known that the neuronal connections, the synapses, are plastic, i.e. the
contribution of each presynaptic neuron to the firing of a postsynaptic neuron
can be independently adjusted. The modulation of effective synaptic strength
can occur on time scales that range from tens or hundreds of milliseconds, to
tens of minutes or hours, to days, and may involve pre- and/or post-synaptic
modifications. The collection of these mechanisms is generally believed to
underlie learning and memory and, hence, it is fundamental to understand their
consequences in the behavior of neurons.(...)
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica