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Deciphering the role of Yap4 phosphorylation under stress conditions
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The existence of molecular mechanisms of response, repair and
adaptation, many of which are greatly conserved across nature, gives
to the cell with the plasticity it requires to adjust to its ever-changing
environment, a homeostatic event that is termed the stress response.
In the budding yeast Saccharomyces cerevisiae there is a particular
family of transcription factors, the Yap family, which has been shown
to have a relevant role in yeast adaptation to several stress
conditions. In particular, Yap1 is the major regulator of the
transcriptional response to oxidative stress and Yap2 and Yap8 play
important roles upon cadmium and arsenic exposure, respectively.(...)
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica