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The drug transporter ABCB1 c.3435C>T SNP influences artemether-lumefantrine treatment outcome
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Orientador(es)
Resumo(s)
Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.
Descrição
Palavras-chave
Angola Artemether-lumefantrine CYP450 Human polymorphism MDR1 SDG 3 - Good Health and Well-being