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http://hdl.handle.net/10362/36450| Título: | The drug transporter ABCB1 c.3435C>T SNP influences artemether-lumefantrine treatment outcome |
| Autor: | Kiaco, Kinanga Rodrigues, António Sebastião do Rosário, Virgílio Gil, José Pedro Lopes, Dinora |
| Palavras-chave: | Angola Artemether-lumefantrine CYP450 Human polymorphism MDR1 SDG 3 - Good Health and Well-being |
| Data: | 21-Set-2017 |
| Resumo: | Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10362/36450 |
| DOI: | https://doi.org/10.1186/s12936-017-2006-6 |
| Aparece nas colecções: | NMS: ToxOmics - Artigos em revista internacional com arbitragem científica |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| The_drug_transporter_ABCB1_3435CT_SNP_influences_artemether_lumefantrine_treatment_outcome.pdf | 801,94 kB | Adobe PDF | Ver/Abrir |
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