Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/36450
Título: The drug transporter ABCB1 c.3435C>T SNP influences artemether-lumefantrine treatment outcome
Autor: Kiaco, Kinanga
Rodrigues, António Sebastião
do Rosário, Virgílio
Gil, José Pedro
Lopes, Dinora
Palavras-chave: Angola
Artemether-lumefantrine
CYP450
Human polymorphism
MDR1
Data: 21-Set-2017
Resumo: Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.
Peer review: yes
URI: http://hdl.handle.net/10362/36450
DOI: https://doi.org/10.1186/s12936-017-2006-6
Aparece nas colecções:NMS-FCM: ToxOmics - Artigos em revista internacional com arbitragem científica

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