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Protein folding, metal ions and conformational states: the case of a di-cluster ferredoxin
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Resumo(s)
Metal ions are present in over thirty percent of known proteins. Apart from a well
established function in catalysis and electron transfer, metals and metal centres
are also important structural elements which may as well play a key role in
modulating protein folding and stability. In this respect, cofactors can act not only
as local structural stabilizing elements in the native state, contributing to the
maintenance of a given specific structural fold, but may also function as potential
nucleation points during the protein folding process...
Descrição
Dissertation presented to obtain the PhD degree in Biochemistry at the Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa