ITQB: RSM - PhD Theses
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- Biophysical view of electrocatalysis of immobilized DyP-type peroxidases for improved biotechnological applicationsPublication . Boloto Barbosa, Catarina; Todorovic, Smilja; Oliveira Martins, Lígia"Dye-decolorizing Peroxidases (DyP) are recently discovered heme-containing enzymes that share no similarity with classical peroxidases in terms of their sequence or structure. DyPs couple the reduction of hydrogen peroxide (H2O2) with the oxidation of structurally different substrates, including synthetic azo and anthraquinone dyes, phenolic and nonphenolic lignin units, and kraft lignin, among others. Due to their catalytic properties, ease of production, and stability, these enzymes have great potential for biotechnological applications, e.g., biocatalysts in electrochemical biosensors for H2O2 detection or dye remediation of wastewater generated by industries. (...) "
- Functional, structural and biophysical view of repair of oxidation damaged DNA in bacteria and ManPublication . Rollo, Filipe Andrade Godinho Garcia; Todorovic, Smilja; Moe, Elin"Living organisms have developed multiple DNA repair machinery to maintain genome integrity. One of the most severe damages that can be inflicted on DNA is oxidation damage. These damages are mainly caused by Reactive Oxygen Species (ROS) which are generated by endogenous sources, such as byproducts of cellular processes (e.g., respiration), or exogenous sources (e.g., environmental stressors and chemicals). Repairing these damages is crucial for genome maintenance and preventing the accumulation of mutations that can contribute to various diseases in humans. The main mechanism responsible for the detection and repair of oxidation damaged bases in DNA is Base Excision Repair (BER).(...)"