ITQB: BN - PhD Theses
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- Study of seasonal weight loss tolerance in small ruminants-an NMR-metabolomics approachPublication . Palma, Mariana; Matzapetakis, Manolis; Almeida, André Martinho deSmall ruminants are very important in the tropics and the Mediterranean. In these regions, pasture scarcity during the dry season leads to Seasonal Weight Loss (SWL), one of the major problems in ruminant production. However, some breeds present higher tolerance to SWL. Understanding the physiological mechanisms by which breeds are able to cope with SWL is of utmost importance in animal selection. We studied two dairy goat breeds (Majorera and Palmera) and three breeds of meatproducing sheep (Merino, Dorper and Damara), with different levels of tolerance to SWL.(...)
- Structure and dynamics of the NO sensing domain of the human soluble Guanylate CyclasePublication . Almeida, Meire; Matzapetakis, ManolisSoluble guanylate cyclase (sGC) is a heterodimeric heme-protein composed of two subunits called α and β [1-5]. The most common heterodimeric form is the combination of α1 with β1 subunits [1]. The α1 (80KDa) and β1 (70 KDa) subunits are 690 and 619 amino acids in length respectively, and are encoded by the genes, GUCY1A2 and GUCY1A3 respectively [3].(...)