Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance

Nakatani, Yoshio; Opel-Reading, Helen K; Merker, Matthias; Machado, Diana; Andres, Sönke; Kumar, S Siva; Moradigaravand, Danesh; Coll, Francesc; Perdigão, João; Portugal, Isabel; Schön, Thomas; Nair, Dina; Devi, K R Uma; Kohl, Thomas A; Beckert, Patrick; Clark, Taane G; Maphalala, Gugu; Khumalo, Derrick; Diel, Roland; Klaos, Kadri; Aung, Htin Lin; Cook, Gregory M; Parkhill, Julian; Peacock, Sharon J; Swaminathan, Soumya; Viveiros, Miguel; Niemann, Stefan; Krause, Kurt L; Köser, Claudio U

http://hdl.handle.net/10362/32683

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Autores

Nakatani, Yoshio

Opel-Reading, Helen K

Moradigaravand, Danesh

Coll, Francesc

Perdigão, João

Portugal, Isabel

Resumo(s)

A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine

Descrição

Palavras-chave

Alanine racemase Cycloserine Mycobacterium tuberculosis complex Mycobacterium bovis Bovine tuberculosis Real-time PCR Biochemistry, Genetics and Molecular Biology (miscellaneous) Infectious Diseases SDG 3 - Good Health and Well-being

URI

http://hdl.handle.net/10362/32683

DOI

10.1128/AAC.01575-17

Coleções

IHMT: MM - Artigos em revista internacional com arbitragem científica

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