Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10362/32683| Título: | Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance |
| Autor: | Nakatani, Yoshio Opel-Reading, Helen K Merker, Matthias Machado, Diana Andres, Sönke Kumar, S Siva Moradigaravand, Danesh Coll, Francesc Perdigão, João Portugal, Isabel Schön, Thomas Nair, Dina Devi, K R Uma Kohl, Thomas A Beckert, Patrick Clark, Taane G Maphalala, Gugu Khumalo, Derrick Diel, Roland Klaos, Kadri Aung, Htin Lin Cook, Gregory M Parkhill, Julian Peacock, Sharon J Swaminathan, Soumya Viveiros, Miguel Niemann, Stefan Krause, Kurt L Köser, Claudio U |
| Palavras-chave: | Alanine racemase Cycloserine Mycobacterium tuberculosis complex Mycobacterium bovis Bovine tuberculosis Real-time PCR Biochemistry, Genetics and Molecular Biology (miscellaneous) Infectious Diseases SDG 3 - Good Health and Well-being |
| Data: | Dez-2017 |
| Resumo: | A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine |
| Descrição: | Copyright © 2017 Nakatani et al. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10362/32683 |
| DOI: | https://doi.org/10.1128/AAC.01575-17 |
| ISSN: | 0066-4804 |
| Aparece nas colecções: | IHMT: MM - Artigos em revista internacional com arbitragem científica |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Antimicrob._Agents_Chemother._2017_Nakatani_.pdf | 713,18 kB | Adobe PDF | Ver/Abrir | |
| Role_of_alanine_racemase_mutations_in_Mycobacterium_tuberculosis_D_cycloserine_resistance.pdf | 714,09 kB | Adobe PDF | Ver/Abrir |
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