Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/23262
Título: Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation
Autor: Papaspyridonos, Marianna
Matei, Irina
Huang, Yujie
Andre, Maria do Rosario
Brazier-Mitouart, Helene
Waite, Janelle C.
Chan, April S.
Kalter, Julie
Ramos, Ilyssa
Wu, Qi
Williams, Caitlin
Wolchok, Jedd D.
Chapman, Paul B.
Peinado, Hector
Anandasabapathy, Niroshana
Ocean, Allyson J.
Kaplan, Rosandra N.
Greenfield, Jeffrey P.
Bromberg, Jacqueline
Skokos, Dimitris
Lyden, David
Palavras-chave: SELF-RENEWAL CAPACITY
REGULATORY T-CELLS
TGF-BETA
DENDRITIC CELLS
PERIPHERAL-BLOOD
PROGENITOR CELLS
CANCER-PATIENTS
DIFFERENTIATION
PROTEINS
MELANOMA
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
Data: 29-Abr-2015
Resumo: A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive 'macroenvironment' mediated in part through tumour-secreted factors. Here we demonstrate that upregulation of the Inhibitor of Differentiation 1 (Id1), in response to tumour-derived factors, such as TGFβ, is responsible for the switch from dendritic cell (DC) differentiation to myeloid-derived suppressor cell expansion during tumour progression. Genetic inactivation of Id1 largely corrects the myeloid imbalance, whereas Id1 overexpression in the absence of tumour-derived factors re-creates it. Id1 overexpression leads to systemic immunosuppression by downregulation of key molecules involved in DC differentiation and suppression of CD8 T-cell proliferation, thus promoting primary tumour growth and metastatic progression. Furthermore, advanced melanoma patients have increased plasma TGFβ levels and express higher levels of ID1 in myeloid peripheral blood cells. This study reveals a critical role for Id1 in suppressing the anti-tumour immune response during tumour progression and metastasis.
Peer review: yes
URI: http://www.scopus.com/inward/record.url?scp=84928884360&partnerID=8YFLogxK
DOI: https://doi.org/10.1038/ncomms7840
ISSN: 2041-1723
Aparece nas colecções:NMS-FCM: ToxOmics - Artigos em revista internacional com arbitragem científica

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
ncomms7840.pdf2,29 MBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.