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Orientador(es)
Resumo(s)
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps ofNAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.
Descrição
This study was supported by Fundacao para a Ciencia e Tecnologia (FCT) Grants PTDC/DTP-EPI/0207/2012 and PTDC/BIM-MET/0486/2012 and by the Portuguese Diabetes Society (SPD).
Palavras-chave
RISK-FACTORS TOLL-LIKE RECEPTORS HEPATOCELLULAR-CARCINOMA FRUCTOSE FATTY LIVER-DISEASE INDUCED HEPATIC STEATOSIS INSULIN-RESISTANCE STELLATE CELLS ENDOPLASMIC-RETICULUM NONALCOHOLIC STEATOHEPATITIS FATTY LIVER-DISEASE TOLL-LIKE RECEPTORS INDUCED HEPATIC STEATOSIS INSULIN-RESISTANCE NONALCOHOLIC STEATOHEPATITIS HEPATOCELLULAR-CARCINOMA ENDOPLASMIC-RETICULUM STELLATE CELLS RISK-FACTORS FRUCTOSE SDG 3 - Good Health and Well-being