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The role of serotonin in behavior
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| 41.2 MB | Adobe PDF |
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Serotonin (5-hydroxytryptamine, 5-HT) is a major
neuromodulator linked to a disparate set of brain functions and
disorders including depression and anxiety, but its fundamental
roles in behavior remain a mystery. Three main theories for 5-HT
function attempt to unravel how this complex neuromodulator
acts in the brain: 1) behavioral inhibition, 2) sensorimotor
hypothesis and 3) reward action. The vast literature in the 5-HT
field is hard to reconcile and presents ambiguous results, due in
part to the limitations of traditional pharmacological and
physiological methods.(...)