A carregar...
Publicação
Exposição ocupacional a citostáticos e efeitos sobre a saúde
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 501.46 KB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
R E S U M O - Os citostáticos são genotóxicos e não completamente seletivos para as células neoplásicas,
podendo afetar o genoma das células normais. Está comprovada a sua genotoxicidade
em modelos experimentais e doentes tratados com quimioterapia. Os profissionais de
saúde responsáveis pela sua preparação e administração apresentam risco de sofrer efeitos
adversos para a saúde, tendo sido comprovado por diversos estudos haver contaminação
generalizada do ambiente e de superfícies de trabalho. Os procedimentos de segurança
e equipamentos de proteção individual têm sido insuficientes para evitar a absorção,
evidenciada por quantidades mensuráveis de citostáticos na urina, e o aumento de indicadores
biológicos de genotoxicidade. São revistos os efeitos para a saúde decorrentes desta
exposição.
A B S T R A C T - Anticancer drugs share DNA-damaging properties affecting not only target-cells, but also non tumour cells. Its genotoxicity has been demonstrated in experimental models and in cancer patients treated with chemotherapy. Health care personnel involved in the preparation and administration of these agents are at risk for adverse health effects, since environmental sampling studies demonstrated widespread contamination of work surfaces and utensils. Adherence to safety guidelines and proper use of personal protective equipment are insufficient to prevent significant absorption, evidenced by the presence of detectable amounts of drugs in urine samples and increased frequency of genotoxicity biomarkers. The evidence regarding adverse health effects on workers occupationally exposed to anticancer agents is reviewed.
A B S T R A C T - Anticancer drugs share DNA-damaging properties affecting not only target-cells, but also non tumour cells. Its genotoxicity has been demonstrated in experimental models and in cancer patients treated with chemotherapy. Health care personnel involved in the preparation and administration of these agents are at risk for adverse health effects, since environmental sampling studies demonstrated widespread contamination of work surfaces and utensils. Adherence to safety guidelines and proper use of personal protective equipment are insufficient to prevent significant absorption, evidenced by the presence of detectable amounts of drugs in urine samples and increased frequency of genotoxicity biomarkers. The evidence regarding adverse health effects on workers occupationally exposed to anticancer agents is reviewed.
Descrição
Palavras-chave
Citostáticos Exposição ocupacional Efeitos para a saúde Anticancer drugs Occupational exposure Health effects
Contexto Educativo
Citação
Editora
Universidade Nova de Lisboa, Escola Nacional de Saúde Pública