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Whole-brain mechanisms of delay and trace conditioning in larval zebrafish
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Orientador(es)
Resumo(s)
"Classical conditioning—the association between two stimuli, in which one predicts the occurrence of the other—is a fundamental form of associative learning and a powerful framework for investigating the neural basis of prediction and memory. This thesis presents the development and systematic refinement of a classical conditioning paradigm in larval zebrafish, designed for compatibility with in vivo high-resolution whole- brain imaging and capable of probing both delay and trace conditioning. The paradigm employs an aversive unconditioned stimulus (US) via optovin- induced activation of TRPA1b channels, paired with a visual conditioned stimulus (CS) in head-restrained larvae. (...)"
Descrição
Palavras-chave
larval zebrafish long-term memory NMDA receptor head-restrained preparation optovin delay and trace conditioning