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Publicação
Engineering Ferritin Nanoparticles for Vaccine Development
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 10.57 MB | Adobe PDF |
Orientador(es)
Resumo(s)
"Ferritin is a 24-mer self-assembling, biocompatible, and stable protein
nanoparticle, making it a promising scaffold for vaccine development. Its
ability to present antigens in a repetitive, particulate form enhances
interaction with antigen-presenting cells and can boost immune responses.
Most ferritin-based vaccine candidates developed to date rely on genetic
fusion to display antigens; while effective, this strategy can lead to improper
antigen folding, steric hindrance, and limited adaptability. In contrast,
modular assembly strategies can overcome these limitations by enabling
controlled antigen conjugation, offering greater design flexibility and rapid
adaptability to emerging pathogens.(...)"
Descrição
Palavras-chave
ferritin nanoparticles structural characterization vaccine platforms antigen conjugation nanoparticle design