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Publicação
Six-year Study on Mucocutaneous Herpes Simplex Virus Infections at the Largest Tertiary Teaching Hospital in Portugal
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Orientador(es)
Resumo(s)
Herpes simplex virus (HSV) infections are widespread among humans. Their diagnosis is predominantly clinical, but its laboratory confirmation is increasingly encouraged. We conducted a 6-year retrospective, observational study of polymerase chain reaction (PCR) confirmed mucocutaneous HSV infections in the largest Portuguese tertiary teaching hospital. Throughout this period, a total of 947 PCR herpesvirus tests in mucocutaneous swabs were performed, 448 of which tested positive (266 for HSV). Regarding the PCR-confirmed mucocutaneous HSV infections, HSV-1 was the main cause of orolabial herpes and HSV-2 of genital herpes. A significant proportion of patients were immunocompromised, demonstrating the risk for herpesvirus infection and reactivation in this setting. HSV-1 genital herpes was more common in women, younger individuals and had a lower rate of recurrences. This study demonstrates the variable clinical spectrum of HSV infections, and the importance of their laboratory confirmation, as the recognition of the specific pathogen may determine optimal management and prognosis.
Descrição
Funding Information: This study was performed after being authorized by Centro Hospitalar Universitário Lisboa Norte Health Ethics Committee, Portugal (Comissão de Ética do Centro Académico de Medicina de Lisboa), process No. 335/22, February 17th, 2023. All experiments were performed in full compliance with relevant laws and institutional guidelines and in full compliance with the ethical standards set forth in the Declaration of Helsinki. Publisher Copyright: © 2025 AEDV
Palavras-chave
Genital herpes Herpes simplex virus type 1 Herpes simplex virus type 2 Oral herpes simplex Polymerase chain reaction Pathology and Forensic Medicine Histology Dermatology