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Arsobal in the treatment of rhodesian sleeping- Sickness
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Descrevemos acima os resultados obtidos com o arsobal. Foram tratados três grupos num total de 165 casos.
Todos os doentes estiveram hospitalizados durante o tra tamento que é o procedimento geral em Moçambique.
A dose do arsobal em todos os casos foi de 3,6 mgrs. por kg . do peso do corpo. O número e a sequência das injecções variou algumas vezes com o fim de experimentar a droga, outras vezes conforme as condições dos doentes.
Quase todos os casos foram acompanhados durante um período médio de 6 a 14 meses.
Conforme as nossas pesquisas o arsobal é de real valor no tratamento do T . rhodesiense da doença do sono no estado nervoso, mesmo nos casos em que o uso prévio da triparsamide tinha falhado .
Relatámos os casos fatais que se seguiram ao tratamento do arsobal.
Só um único caso foi tratado no princípio da doença. O doente curou-se.
Achamos que o arsobal é demasiado perigoso para ser aplicado no princípio da doença, visto que o antrypol e a pentamidíne facilmente curam estes casos.
We have described above thc results obtained with arsobal. Three groups with a total of 165 cases were treated. Ali patients were in hospital during treatment this being the procedure in Mozambique. The dosage arsobal in ali cases was one of 3,6 mgrs. per kgr. of body weight. The number and the sequence of the injections varied sometimes for the sake of experimenting with the drug, other times according to the condition of the patients. Nearly ali cases were followed up for an average period of 6 to 14 months. According to our findings arsobal is of definite value in the treatment of T . rhodesiense sleeping sickness in the nervous stage, even in those cases where previous use of tryparsamide had failed. We have mentioned the fatal accidents following the arsobal treatment. Only ooe early case was treated. The patient got cured. We think that arsobal is too dangerous to be used in the early stage of the disease since antrypol and pentamidine (isethionate) easily cure these cases.
We have described above thc results obtained with arsobal. Three groups with a total of 165 cases were treated. Ali patients were in hospital during treatment this being the procedure in Mozambique. The dosage arsobal in ali cases was one of 3,6 mgrs. per kgr. of body weight. The number and the sequence of the injections varied sometimes for the sake of experimenting with the drug, other times according to the condition of the patients. Nearly ali cases were followed up for an average period of 6 to 14 months. According to our findings arsobal is of definite value in the treatment of T . rhodesiense sleeping sickness in the nervous stage, even in those cases where previous use of tryparsamide had failed. We have mentioned the fatal accidents following the arsobal treatment. Only ooe early case was treated. The patient got cured. We think that arsobal is too dangerous to be used in the early stage of the disease since antrypol and pentamidine (isethionate) easily cure these cases.
Descrição
Palavras-chave
Doença do sono Arsobal no tratamento
Contexto Educativo
Citação
Editora
Instituto de Medicina Tropical