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Investigating the relevance of nuclear deformability in zebrafish neuroepithelia
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Resumo(s)
"Nuclear positioning is a fundamental process in cellular and developmental biology. In
neuroepithelia, the apical migration of nuclei before mitosis is crucial for tissue integrity and
successful neurogenesis. While the cytoskeletal mechanisms driving this movement have been
extensively studied, the influence of nuclear material properties on nuclear positioning
remains less understood. A key determinant of nuclear deformability is Lamin A/C, an
intermediate filament of the nuclear lamina. In vitro studies have shown that low Lamin A/C
levels enhance nuclear deformability, facilitating cell migration in confined environments.
Interestingly, during early development, including in confined neuroepithelia, Lamin A/C is
expressed at low levels, suggesting a potential link between nuclear deformability and efficient
nuclear positioning in developing tissues.(...)"
Descrição
Palavras-chave
zebrafish tissue material properties neuriepithelia nuclear migration