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Speeding up the experiment-to-model lead time: using a flexible microscope platform to explore the neural correlates of the short-term memory of larval zebrafish
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Resumo(s)
"Cognitive processes have dynamics that evolve across multiple brain
areas, presenting a challenge for studying the mechanisms of the under-
lying neural circuits. Such is the case for working memory, a central com-
ponent of cognition where sensory information is temporarily retained in
a form that can be processed and used to assist future decision-making.
Through recent optical and genetic advances that allow non-invasive
recordings from large neural populations, it is now possible to tackle
challenging research questions such as studying the neural basis of work-
ing memory. Answering such questions, however, demands multimodal
experimental assays, which involve collecting vast amounts of data from
multiple sources and controlling diverse hardware setups.
In this thesis, I describe the technical advances and behavioral
and imaging experiments that led to the discovery of a novel working
memory-like process in zebrafish.(...)"
Descrição
Palavras-chave
behavioral zebrafish neural circuitry imaging experiments memory-like