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The cytochalasans
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| 6.53 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Cytochalasans are a fascinating class of natural products that possess an intricate chemical structure with a diverse range of biological activities. They are known for their complex chemical architectures and are often isolated from various fungi. These compounds have attracted attention due to their potential pharmacological properties, including antimicrobial, antiviral, and anticancer effects. For decades, researchers have studied these molecules to better understand their mechanisms of action and to explore their potential applications in medicine and other fields. This review article aims to shed light over the period 2000-2023 on the structural diversities of 424 fungal derived cytochalasans, insights into their biosynthetic origins, pharmacokinetics and their promising therapeutic potential in drug discovery and development.
Descrição
Funding Information: Amr El-Demerdash is thankful to his home universities, University of East Anglia (UK) and Mansoura University (Egypt) for the unlimited support, inside and outside. Elizabeth Skellam is thankful for the National Science Foundation (NSF) for a financial support (Grant number 2048347). Mohamed A. Tammam is humbly dedicating this work to the soul of his sister Dr Mai A. Tammam who passed away on 19 March 2022, was always a kind supporter in all aspects of his life.