Drug Release Kinetics of PLGA-PEG Microspheres Encapsulating Aclacinomycin A

Costa, Mariana Sousa; Ramos, Ana M.; Cardoso, M. Margarida

http://hdl.handle.net/10362/184782

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Autores

Costa, Mariana Sousa

Ramos, Ana M.

Cardoso, M. Margarida

Resumo(s)

The present study evaluates the effect of PEG content on the characteristics of poly(lactic-co-glycolic acid)-polyoxyethylene (PLGA-PEG) microspheres loaded with a small molecular weight drug on the polymer matrix degradation behavior of the polymeric matrix and drug release profile. Aclacinomycin A (ACM) was encapsulated in PLGA-PEG microspheres with varying PEG content (0%, 5%, 10%, or 15%) using the oil-in-water solvent evaporation method. Microspheres were obtained with sizes ranging from 45–70 mm, drug loading around 1.3% and encapsulation efficiencies between 48–70%. The produced microspheres were further characterized in terms of degradation behavior and drug release kinetics. The results showed that while PEG content had minimal impact on drug loading and microsphere size, it significantly influenced the degradation behavior of the microspheres and its weight in the release process. In vitro drug release profiles exhibited a three-phase pattern for all PLGA-PEG microspheres with faster and more extensive ACM release compared to PLGA microspheres, being the release improved with the PEG content increase. The Corrigan model was successfully applied to the release data yielding burst-phase kinetic constants (kb) between 0.082–0.288 and degradation/erosion kinetic constants (k) between 0.054–0.093 day−¹, both of which increased with higher PEG content.

Descrição

This work was supported by national funds from FCT—Fundação para a Ciência e a Tecnologia, Portugal, under projects [POCTI/EQU/46715/2002 from the QCA III/FEDER; PTDC/EQU/EPR/119631/2010. Publisher Copyright: © 2025 by the authors.

Palavras-chave

aclacynomicin release biodegradable polymers controlled release PLGA-PEG copolymers polymer degradation polymeric microparticles Bioengineering Chemical Engineering (miscellaneous) Process Chemistry and Technology