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Differential Urinary Proteomics and Absolute Protein Quantification Reveal Biomarkers of Muscle-Invasive and Non-Muscle-Invasive Bladder Cancer
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Resumo(s)
A comparative urinary proteomic analysis using the Total Protein Approach (TPA) revealed distinct protein abundance profiles between patients with muscle-invasive (MIBC) and non-muscle-invasive bladder cancer (NMIBC), suggesting potential diagnostic utility. Notably, several proteins, including periostin (POSTN), immunoglobulin variable regions (IGLV3-21, IGHV3-49, IGHV5-51), and complement regulator (C4BPB), were found at significantly higher concentrations in the urine of MIBC patients. These findings support their value as non-invasive indicators of tumour aggressiveness. The TPA-based urinary protein signature holds promise for improving early risk stratification, detecting biological features associated with invasive disease, and may inform treatment strategies.
Descrição
PM003/2016). This work received support from Fundação para a Ciência e a Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES) through the projects LA/P/0008/2020 DOI 10.54499/LA/P/0008/2020, UIDP/50006/2020 DOI 10.54499/UIDP/50006/2020 and UIDB/50006/2020 DOI 10.54499/UIDB/50006/2020. HMS acknowledges the Associate Laboratory for Green Chemistry – LAQV (LA/P/0008/2020) DOI 10.54499/LA/P/0008/2020 funded by FCT/MCTES for his research contract. AQF thanks FCT/MCTES for his PhD grant reference 2023.00528.BD. IFD thanks FCT/MCTES for his PhD grant reference 2024.00745.BD.
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Palavras-chave
Bladder cancer Classification Diagnostic Proteomics Total protein approach TPA Biochemistry Molecular Biology Genetics SDG 3 - Good Health and Well-being