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Orientador(es)
Resumo(s)
Background: Most forms of obesity are associated with chronic diseases that remain a global public health challenge. Aims: Despite significant advancements in understanding its pathophysiology, effective management of obesity is hindered by the persistence of knowledge gaps in epidemiology, phenotypic heterogeneity and policy implementation. Materials and Methods: This consensus statement by the European Society for Clinical Investigation identifies eight critical areas requiring urgent attention. Key gaps include insufficient long-term data on obesity trends, the inadequacy of body mass index (BMI) as a sole diagnostic measure, and insufficient recognition of phenotypic diversity in obesity-related cardiometabolic risks. Moreover, the socio-economic drivers of obesity and its transition across phenotypes remain poorly understood. Results: The syndemic nature of obesity, exacerbated by globalization and environmental changes, necessitates a holistic approach integrating global frameworks and community-level interventions. This statement advocates for leveraging emerging technologies, such as artificial intelligence, to refine predictive models and address phenotypic variability. It underscores the importance of collaborative efforts among scientists, policymakers, and stakeholders to create tailored interventions and enduring policies. Discussion: The consensus highlights the need for harmonizing anthropometric and biochemical markers, fostering inclusive public health narratives and combating stigma associated with obesity. By addressing these gaps, this initiative aims to advance research, improve prevention strategies and optimize care delivery for people living with obesity. Conclusion: This collaborative effort marks a decisive step towards mitigating the obesity epidemic and its profound impact on global health systems. Ultimately, obesity should be considered as being largely the consequence of a socio-economic model not compatible with optimal human health.
Descrição
NEXTGENERATIONEU (NGEU) and funded by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006)\u2014(DN. 1553 11.10.2022) to Federico Carbone e Fabrizio Montecucco; (iii) the European Commission, Horizon Europe Framework Programme, PAS GRAS (Grant agreement n. 101080329) to M aria Paula Macedo; (iv) National Science Centre, Poland (grant UMO\u20102021/43/I/NZ3/00510) to Marcin Krawczyk; (v) Project PRIMA 2023\u201325. Box for Health by Tradition & Innovation: promoting sustainable Mediterranean diet by Healthy Foods\u2014B4HT, CUP H93C22000950001; and (vi) National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3\u2014Call for tender No. 341 of 15/03/2022 of Italian Ministry of University and Research funded by the European Union\u2014NextGenerationEU Award Number: Project code PE0000003, Concession Decree No. 1550 of 11/10/2022 adopted by the Italian Ministry of University and Research, CUP D93C22000890001, Project title \u2018Research and innovation network on food and nutrition Sustainability, Safety and Security\u2014Working ON Foods\u2019 (ONFoods), to Piero Portincasa; funding sources had no role in manuscript writing or the decision to submit it for publication. (vii) the Spanish Institute of Health ISCIII (Instituto de Salud Carlos III, Fondo de Investigaci\u00F3n Sanitaria\u2010FEDER Subdirecci\u00F3n General de Evaluaci\u00F3n and Fondos FEDER project PI22/00745, and PI23/00208) and (viii) CIBEROBN to Gema Fr\u00FChbeck; (ix) \u2018Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia\u2019\u2014iNOVA4Health (UIDB/Multi/04462/2020). Open access publishing facilitated by Universita degli Studi di Genova, as part of the Wiley \u2010 CRUI\u2010CARE agreement.
Publisher Copyright:
© 2025 The Author(s). European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.
Palavras-chave
body mass index cardiovascular risk management of obesity metabolic dysfunction-associated steatotic liver disease metabolically healthy obesity obesities obesity obesity definition obesity transition paediatric obesity waist circumference Biochemistry Clinical Biochemistry SDG 3 - Good Health and Well-being