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Orientador(es)
Resumo(s)
Next-generation sequencing (NGS) in HIV drug resistance (HIVDR) testing has the potential to improve both clinical and public health settings, however it challenges the normal operations of quality management systems to be more flexible due to its complexity, massive data generation, and rapidly evolving protocols. While guidelines for quality management inNGSdata have previously been outlined, little guidance has been implemented for NGS-based HIVDR testing. This document summarizes quality control procedures for NGS-based HIVDR testing laboratories using a laboratory information systems (LIS) framework. Here, we focus in particular on the quality control measures applied on the final sequencing product aligned with the recommendations from theWorld Health Organization HIV Drug Resistance Laboratory Network.
Descrição
Funding Information: We acknowledge the Fonds voor Wetenschappelijk Onderzoek Vlaanderen (FWO) (G.0B23.17N) for covering publications costs. Publisher Copyright: © 2020 by the authors.
Palavras-chave
HIV-1 drug resistance Laboratory information systems Next-generation sequencing Quality control Quality management Infectious Diseases Virology SDG 3 - Good Health and Well-being