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Alterations of Mitochondrial related processes during influenza A vírus infection
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Orientador(es)
Resumo(s)
"In this PhD thesis, we investigated how influenza A virus (IAV) reprograms host
mitochondrial dynamics, bioenergetics, metabolism, and immune responses to support
viral replication and evade immune defenses. To address these questions, we utilized 2
IAV strains: the wild-type (WT) A/Puerto Rico/8/34 (PR8), which expresses a full-length
non-structural protein 1 (NS1) capable of suppressing host immune responses, and the
mutant PR8 NS1 N81 strain, which carries a truncation in the NS1 protein at amino acid
81. This mutation impairs the virus's immune evasion capabilities and results in
enhanced activation of the host innate immune response, particularly through the
mitochondrial antiviral signaling protein (MAVS)-mediated signaling pathway. By
comparing these 2 strains, we were able to explore how the presence or absence of
effective immune suppression influences mitochondrial dynamics, bioenergetics, and
metabolism.(...)"
Descrição
Palavras-chave
mitochondrial bioenergetics MAVS-mediated signaling mitochondrial dynamics immune response