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Unveiling the structural basis of the complex between the virulence factor SARS-CoV2 Nsp1 and the host DNA polymerase-alpha
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Resumo(s)
"The work presented in this dissertation focuses on studies of the
Non-structural protein 1 (Nsp1) of SARS-CoV2 (Nsp1SARS-CoV2),
identified as a major virulence factor causing Covid 19. Nsp1 is a
small protein encoded by ORF1a/b and is found only in the a/b-
Coronavirus (a/b-CoV) genera. SARS-CoV2 belongs to the b-CoV,
and Nsp1 proteins from these genera consist of two structural
domains: a globular N-terminal domain (NTD) and a flexible Cterminal
domain (CTD), connected to the NTD by a loop (L) of
approximately 28 amino acids. Despite the low sequence identity
across Nsp1 proteins, they all share the same structural fold for the
NTD.(...)"
Descrição
Palavras-chave
Coronavirus Non-structural protein 1 RNA/DNA nuclease activity divalent metals proteolytic activity