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Seroconversion and seroreversion rates of anti-Strongyloides IgG in rural areas of the Amazon
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Orientador(es)
Resumo(s)
Using a panel study design, we aimed to estimate the seroconversion and seroreversion rates of anti-Strongyloides IgG antibodies from surveys carried out 11 months apart in a rural community in the Amazon Basin in Brazil. We used enzyme immunoassays to measure anti-Strongyloides IgG antibodies in 325 baseline plasma samples and 224 others that were collected 11 months later from residents in the agricultural settlement of Granada, Acre State. We observed anti-Strongyloides IgG antibodies in 21.8% of the baseline samples (which showed that 3.4% of participants had larvae in their stool) and in 23.7% of the follow-up samples. The seroconversion rate estimated at 9.7 episodes/100 person-years at risk agrees with ongoing transmission. Specific antibodies were relatively short-lived and nine (25.0%) of 36 seropositive participants at baseline were seronegative when retested 11 months later. Fecal surveys can severely underestimate the prevalence of S. stercoralis infection in rural Amazonians. Serology provides a field-deployable diagnostic tool to find high-prevalence populations, identify associated risk factors, and monitor intervention programs.
Descrição
Funding Information: We would like to thank the leadership and staff of the Department of Health and Sanitation of Acrelandia for their overall support, Adamilson Luis de Souza for his valuable help during fieldwork, Luis Antoonio Vieira Garcia for the stool examinations, and Estefano Alves de Souza and Bruna de Almeida Luz for data handling. Fieldwork was supported by S\u00E3o Paulo Research Foundation (grants 03/09719-6, 04/00373-2, 2013/04236-9 and 2022/02401-1) and National Council for Scientific and Technological Development (grants 47.0281/2003-0 and 50.4332/2004-0); MUF acknowledges research scholarships from CNPq and Fundacao para a Ciencia e Tecnologia, Portugal (institutional GHTM project, UID/04413/2020); FMP is a CNPq research fellow (310071/2022-4). The funders had no role in study design, data collection and interpretation, or the decision to submit this study for publication. Publisher Copyright: © 2024, Instituto de Medicina Tropical de Sao Paulo. All rights reserved.
Palavras-chave
Brazil Seroconversion Serology Seroreversion Strongyloides Infectious Diseases SDG 3 - Good Health and Well-being