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Quantitative Centromere Epigenetics
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| 7.75 MB | Adobe PDF |
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Resumo(s)
A PhD is like a box of chocolates, …… and in this thesis I will present
what I got. My work has been focused on a cellular structure that is essential
for accurate genome inheritance: the centromere. Centromeres are
chromosomal domains that do not rely on the presence of any specific DNA
sequence. Rather, they are determined by the presence of a histone variant
called CENP-A. Stable transmission of CENP-A containing chromatin is
accomplished through 1) an unusually high level of protein stability, 2) selfdirected
recruitment of nascent CENP-A near existing molecules, and 3)
strict cell cycle regulation of assembly. Together, these features lead to a
self-sustaining loop that allows for epigenetic maintenance of centromeres.(...)
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Biology Molecular Biology