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Publicação
Biology and Interactions of gut anaerobic spore-formers
| Nome: | Descrição: | Tamanho: | Formato: | |
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| 38.85 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
"The gastrointestinal tract of healthy humans harbors bacteria
that are crucial for our health, nutrition and overall well-being.
Approximately 50 to 60% of these bacteria are capable of producing
resilient spores, which are the primary means of transmission from
one host to another. A genomic signature of sporulation within the
human intestinal microbiota includes 66 genes and is predominantly
characterized by genes known to play a role in sporulation, including
those encoding RNA polymerase sigma factors that regulate cell
type-specific gene expression during this process. Notably, about
30% of these signature genes have no known role in sporulation, and
in some cases, they encode products that bear no similarity to any
previously identified proteins. In this study, we explore the function of
some of these genes within the sporulation process, using
Clostridioides difficile as a model organism."
Descrição
Palavras-chave
gastrointestinal tract gut anaerobic phenotypic characterization spoIVB1 spoIVB2