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Orientador(es)
Resumo(s)
COVID-19, the disease caused by SARS-CoV-2, has caused significant morbidity and mortality worldwide. The betacoronavirus continues to evolve with global health implications as we race to learn more to curb its transmission, evolution, and sequelae. The focus of this review, the second of a three-part series, is on the biological effects of the SARS-CoV-2 virus on post-acute disease in the context of tissue and organ adaptations and damage. We highlight the current knowledge and describe how virological, animal, and clinical studies have shed light on the mechanisms driving the varied clinical diagnoses and observations of COVID-19 patients. Moreover, we describe how investigations into SARS-CoV-2 effects have informed the understanding of viral pathogenesis and provide innovative pathways for future research on the mechanisms of viral diseases.
Descrição
Funding Information: The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, the National Science Foundation, or the United States government. APK’s research is supported by the Department of Defense and Swezey & Jewell, Moore and MacKenzie Research Fund. Funding Information: The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, the National Science Foundation, or the United States government. APK’s research is supported by the Department of Defense and Swezey & Jewell, Moore and MacKenzie Research Fund. Funding Information: This work was supported by supplemental funds for COVID-19 research from Translational Research Institute of Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404) to AB, and by a NASA Space Biology Postdoctoral Fellowship (80NSSC19K0426) and Human Research Program Augmentation Award (80NSSC19K1322) to SAN. Publisher Copyright: © 2023, The Author(s).
Palavras-chave
Genetics Genetics(clinical)